Brand name: Capekast
Generic name: Capecitabine
Strength: 500 mg
Manufacturer: Aprazer Healthcare
Dosage form: Tablets
Indication: Colorectal cancer, Breast cancer
Storage: Store at room temperature.
Overview
Capekast is a formulation of a prescription medicine known as Capecitabine. It is prescribed for the treatment of patients suffering from breast cancer, gastric cancer, and colorectal cancer. In patients with breast cancer, this regimen may be given in combination with docetaxel. It is a chemotherapy drug that belongs to the class of antimetabolites. Capekast (Capecitabine) tablets are available in the strength of 500 mg.
Pharmacodynamics
Capecitabine is an antineoplastic fluoropyrimidine carbamate that is used to treat metastatic breast cancer and colon cancer. It’s a systemic prodrug given orally that has minimal pharmacologic activity until it’s transformed to fluorouracil by enzymes found in higher doses in various cancers. Fluorouracil then metabolized 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) and 5-fluorouridine triphosphate in both normal and malignant cells (FUTP).
Interactions
The following are the possible interactions that are associated with the use of Capecitabine tablets.
With Medicines
- Adalimumab
- Infliximab
- Ozanimod
- Ponesimod
- Siponimod
- Anisindione
- Fingolimod
- Baricitinib
- Cladribine
With Diseases
- Infections
- Coronary artery disease
- Renal dysfunction
- Dehydration
- Hepatic dysfunction
- Myelosuppression
With Alcohol
Alcohol can interact with the components of Capekast (Capecitabine) tablets. However, limited studies are available to justify that.
Alternate Brands
The following are some of the substitutes for Capekast (Capecitabine) tablets.
- Capegard
- Capebiine
- Xeloda
- Captabin
- Capetero
Contraindications
The following are the significant contraindications of Capekast (Capecitabine) tablets.
- An infection
- Very serious loss of body water
- Anemia
- Decreased blood platelets
- Low levels of neutrophils
- Coronary artery disease
- Abnormal heart rhythm
- Abnormal EKG with QT changes from birth
- Stomatitis
- Necrotizing enterocolitis
- Liver problems
- The high bilirubin amount in the blood
- Excessive diarrhea
- Pregnancy
- A mother who is producing milk and nursing
- Dihydropyrimidine dehydrogenase deficiency
- Chronic kidney disease
- Kidney disease