TS-ONE

DESCRIPTION

PACKAGE


OVERVIEW & USAGE

Brand name:- TS-ONE

Composition:- Tegafur, Gimeracil, Oteracil Potassium

Manufacturer:- Taiho

Dosage form:- Capsule

Strength:- 20mg

Packaging:- Strip

Indication:- Gastric Cancer

Storage:- Store below 25°C.

Overview

TS-ONE Capsule is an anti-cancer medicine used in the treatment of Gastric Cancer with other medications like Cisplatin. It is also used in the treatment of head and neck cancer, lung, biliary tract, breast, pancreatic, and colorectal cancer. TS-ONE capsules comprise three agents namely tegafur (FT), gimeracil (CDHP), and oteracil potassium (Oxo). It is a prescription medicine, used with other medications to treat certain types of cancers. It is not prescribed for use in pregnant and breastfeeding women. This medicine may cause certain side effects. It is important to know the relevant ways to manage the side effects before the administration of the capsules. Make sure to consult your physician.

Pharmacodynamics

The antitumor activity of TS-ONE after its administration (orally) is based on 5-fluorouracil (5-FU) which tends to appear gradually in the body via the transformation of FT. CDHP increased the 5-FU’s concentration, which is converted from FT, by selectively and reversibly inhibiting DPD, a catabolic enzyme of 5-FU, which is particularly distributed in the liver. 5-fluoronucleotides, phosphorylated metabolites of 5-FU, are highly maintained in tumor tissues, thereby enhancing the antitumor activity in proportion to the increase in the concentration of 5-FU in the body. Oxo works to selectively inhibit the production of 5-fluoronucleotides from 5-FU by enabling the distribution in the gastrointestinal tissue as a result of the medicine’s administration and selectively inhibiting orotate phosphoribosyltransferase.

Contraindications

TS-ONE Capsules are not indicated for use in the following cases. However, if its use can not be avoided during any of these situations, make sure to know the risks associated with the medicine before the administration.

  • Hypersensitivity
  • Pregnancy
  • Lactation (Breastfeeding women)
  • Allergy
    • Tegafur
    • Gimeracil
    • Oteracil potassium
    • Any other ingredient of the medicine

 Side Effects

TS-ONE Capsules may cause certain side effects. Some of the common and serious side effects are stated below. Make sure to contact your healthcare professional if side effects occur after administration or last longer than usual.

Common Side Effects

  • Fever
  • Headache
  • Chills
  • Nausea
  • Sore throat
  • Malaise
  • Dehydration
  • Diarrhea
  • Abdominal pain
  • Speech disorder
  • Sensory disturbance
  • Tiredness
  • Lack of energy
  • Vomiting
  • Irregular heartbeat
  • Unusual bleeding
  • Bruising
  • Skin rash
  • Itching
  • Yellowing of skin
  • Mouth sores

Serious Side Effects

  • Thrombocytopenia
  • Hemolytic anemia
  • Severe hepatic disorder
  • Dyspnea
  • Shortness of breath
  • Cardiac failure
  • Palpitation
  • Chest pain
  • Gastrointestinal ulcer
  • Hemorrhage
  • Low red blood cell count
  • Low white blood cell count
  • Dark-colored stools
  • Dark-colored urine

Dosage

Normal Dose

The doctor will recommend the dose strength and frequency of your dose as per your health condition and the body’s tolerance. Take the capsule as a whole with water. Do not crush or cut it.

Missed Dose

If you miss a dose of TS-ONE Capsule, make sure to contact your healthcare professional before taking the next dose. Do not try to cope with the missed dose by doubling the strength of your next dose.

Overdose

Overdose may cause certain adverse symptoms. If you experience such symptoms, make sure to contact your healthcare professional before taking any other step. If symptoms worsen your medical condition, seek emergency help from a medical center/hospital.

Warnings And Precautions

Special Population

  • Pregnancy
    • TS-ONE Capsules are not indicated for use in pregnant women. Severe adverse reactions may be caused if this medicine is administered during pregnancy.
  • Nursing women
    • Nursing women should not take TS-ONE Capsules as this medicine may cause a fatal effect on the growth of the baby and may also lead to toxicity.
  • Kidney disease
    • In patients having known kidney disease, TS-ONE Capsules should be administered either cautiously or be avoided.
  • Liver disease
    • In patients having known liver disease, TS-ONE Capsules should be administered either cautiously or be avoided.

General Warnings

  • Driving
    • TS-ONE Capsules may cause dizziness or lack of concentration. Therefore, it is important to avoid driving or any other activity that needs high concentration.
  • Alcohol consumption
    • Consumption of alcohol with TS-ONE capsules should be avoided. It may have a serious effect on the health of the patient.
  • Smoking
    • Smoke (of any kind) should be avoided, in general. However, its interaction with this medication is not discovered yet. Consult your physician.
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