Z-PAC

Brand name- Z-Pac

Generics- Paclitaxel

Manufacturer- RPG Life Sciences Ltd.

Dosage form- Injection

Route of Administration- Intravenous (IV)

Strength- 260mg

Composition- Paclitaxel

Packaging- vial

Indication- non-small cell lung cancer (NSCLC), Breast cancer, Ovarian cancer, and pancreatic cancer.

Storage- Do not store above 25°C. Keep the vial safe and protect it from light.

After dilution medicine stored in a refrigerator (2 to 8°C) for no more than 24 hours

Class of drug- Taxane derivative

Mechanism Of Action

It does its action by interfering with microtubule structures which assist the cancer cells to divide and multiply. This decreases the growth of cancer cells and eventually kills them.

Side Effects-

Side effects of Z-Pac include fever, low blood cell counts, feeling weak or tired, bleeding, trouble breathing, hair loss, numbness or tingling, swelling in your face, hands, or feet, sores or white patches in or around your mouth, joint or muscle pain, nausea, vomiting, diarrhea and mild redness or tenderness where the medicine was injected.

Pharmacodynamics

It is study of drug effects and what the medicine does to the body

Z-Pac has different pharmacodynamic effects in each disorder like breast cancer, ovarian cancer, and advanced non-small cell lung carcinoma.

Pharmacokinetics

Study of what the body does to the medicine. After oral administration of a single dose, the time of peak concentration, Tmax, was between 1 and 4 hr.

Minimum effect concentration (MEC)

A minimum concentration of medicine in blood is required for producing the therapeutic effects. Its predefined therapeutic range is not known.

Minimum toxic concentration (MTC)

Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC range is not known.

Bioavailability Rate

Bioavailability is low (about 30%).

Shelf Life

Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at the time of manufacture.

Its shelf life is 12 months.

Usage

Which disease area

non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and pancreatic cancer

Alternate Brands

Oncotaxel 260mg Injection- Sun Pharmaceutical Industries Ltd

Cytax 260mg Injection- Intas Pharmaceuticals Ltd

Petaxel 260mg Injection- Biochem Pharmaceutical Industries

Tortaxel 260mg Injection- Torrent Pharmaceuticals Ltd