TRUSTIVA

DESCRIPTION

  • Composition : Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate
  • Manufacturer : Hetero
  • Indication : Anti HIV
  • Packaging : Bottle
  • Dosage Form : Tablet

PACKAGE

  • 200mg
  • 300mg
  • 600mg
Category:

Brand Name: Trustiva
Generic Name: Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz
Manufacturer: Hetero
Dosage Form: Tablet
Strength: 200mg, 300mg and 600mg
Composition: Emtricitabine(200mg) + Tenofovir disoproxil fumarate(300mg) + Efavirenz(600mg)
Indication: HIV
Storage: Store at room temperature

Overview
Trustiva (Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz) tablet is used in the treatment of HIV (human immunodeficiency virus). This medication boosts your immune system to fight against infection and prevents the virus from multiplying. Trustiva tablet increases the CD4 cell (white blood cells that protect against infection) count in your blood. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.

Pharmacodynamics
Emtricitabine (Trustiva):- a synthetic nucleoside analog of cytidine, is phosphorylated by cellular enzymes to form Emtricitabine (Trustiva) 5′-triphosphate. Emtricitabine inhibits the activity of the HIV-1 reverse transcriptase (RT) by competing with the natural substrate deoxycytidine 5′-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.

Tenofovir Disoproxil Fumarate (Trustiva):- is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA-chain termination.

Efavirenz (Trustiva):- belongs to the NNRTI (non-nucleoside reverse transcriptase inhibitors) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs (reverse transcriptase inhibitors) inhibit the same target, reverse transcriptase enzyme, an essential viral enzyme that transcribes viral RNA into DNA. RTIs bind the enzyme’s active site, NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket. Efavirenz is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.

Usage
Trustiva tablet is a combination of three anti-HIV medicines: Emtricitabine, Tenofovir disoproxil fumarate, and Efavirenz. This medication is not a permanent cure for HIV it only prevents the multiplication of infection in human cells. It is important to take this medicine as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. The recommended dose of Trustiva medicine is decided by a doctor according to your previous medical condition and response to the treatment.

Interactions
Trustiva tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions
Fluconazole

Cisplatin

Tobramycin

Gentamicin

Methotrexate

Lamivudine

Ciprofloxacin

Disease Interactions
Increase in cholesterol levels

Hepatic impairment

CNS orders

Renal dysfunction

Alcohol Interaction
Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindications
Trustiva tablet is not recommended for use in patients with liver disease.

Do not take this medicine if you are allergic to Emtricitabine, Tenofovir disoproxil fumarate, and Efavirenz.

Trustiva tablet is not recommended in patients known to be hypersensitive.

This medicine is not recommended for use in patients with severe renal impairment.
Substitutes
Teefavir
Teevir

Viraday

Frostavir

Virotrenz

Side Effects
This medicine may cause some side effects. Discuss the risks and benefits of the Trustiva tablets with the doctor before starting the treatment.

Common Side Effects
Dizziness

Unusual sweating

Skin rash

Itching

Indigestion

Constipation

Redness of skin

Headache

Taste change

Blurred vision

Confusion

Weight loss

Sweating

Mood changes

Nausea

Fever

Chills

Peripheral neuropathy

Stomach ache

Diarrhea

Blood in urine

Irregular heartbeat

Abnormal dream

Confusion

Note – immediately contact your health care provider and medical practitioner if any side effects occur.

Dosage
Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule.

Missed Dose
It is advisable not to miss a dose. If you miss a scheduled dose of Trustiva tablets, contact your doctor immediately.

Overdose
In case of an overdose of Trustiva tablets, the doctor will provide emergency medical treatment.

Warning
Before starting treatment with Trustiva medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.

Contraception

Use suitable methods of contraception to prevent pregnancy while taking Trustiva medicine.

Children and adolescents

Trustiva tablets are not recommended for use in children under the age of 12.

Warnings For Female
Pregnancy

Do not use Trustiva medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.

Breastfeeding

This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Trustiva (Emtricitabine + Tenofovir disoproxil fumarate + Efavirenz).

Precautions
Trustiva increases the risk of lactic acidosis.

This medication should be used with caution in some patients because it may increase the risk of CNS side effects like drowsiness, hallucinations, etc.

Close monitoring of bone mineral density is required during treatment with this medicine.

This medication may increase the risk of immune reconstitution syndrome.

Cautions
Do not drive or operate heavy machinery.

Do not crush or break the tablet.

Not safe for pregnant women.

Do not breastfeed while receiving this medication.

DESCRIPTION

  • Composition : Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate
  • Manufacturer : Hetero
  • Indication : Anti HIV
  • Packaging : Bottle
  • Dosage Form : Tablet

PACKAGE

  • 200mg
  • 300mg
  • 600mg
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