HEPCINAT

Medicine Details
Brand name – Hepcinat
Generic name – Sofosbuvir
Manufacturer – Natco Pharma Ltd.
Salt composition – Sofosbuvir 400mg
Storage – Store at room temperature (10-30°C)
Dosage form – Oral (tablet)
Strength – 400mg
Packaging – Bottle of 28 tablets
Gender – Unisex
Prescription required – Yes
Indication – Used in the treatment of chronic Hepatitis C Virus (HCV) infection

Description
Hepcinat (Sofosbuvir) 400mg tablet is an antiviral medication, used along with other medications, in the treatment of chronic Hepatitis C Virus (HCV) infection in adults. This medicine works to lower the growth and multiplication of virus in the body and helps to eliminate the virus from the body.

Pharmacodynamics
Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half life of Sofosbuvir is 0.4 hours, and the half life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in urine, 2.5% in expired air recovery and 14% in feces.

Ingredients
The active ingredient of Hepcinat tablet is Sofosbuvir 400mg.

Usage Of Medicine
Hepcinat 400mg tablet is used to treat chronic (long-lasting) Hepatitis C Virus (HCV) infection in adults.