DUOVIR

Brand Name: Duovir
Generic Name: Lamivudine and Zidovudine
Manufacturer: Cipla
Dosage Form: Tablet
Strength: 150mg/300mg
Composition: Lamivudine(150mg) and Zidovudine(300mg)
Indication: HIV
Packaging: 60 tablets
Storage: Store at room temperature

Overview
Duovir (Lamivudine and Zidovudine) tablet is a combination of two antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication boosts your immune system to fight against infection and prevents the virus from multiplying. Duovir tablet increases the CD4 cell (white blood cells that protect against infection) count in your blood. It is important to take this medicine as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.

Pharmacodynamics
Lamivudine (Duovir):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) in order to disrupt viral DNA synthesis. It can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites work to inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.

Zidovudine (Duovir):- Works to inhibit the activity of HIV-1 reverse transcriptase by competing with its natural nucleotide counterpart thymidine triphosphate for incorporation into newly synthesized viral DNA. It is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). This compound is phosphorylated to active metabolites that compete for incorporation into viral DNA. They work to inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.

Usage
Duovir tablet is a combination of two anti-HIV medicines: Lamivudine and Zidovudine. It helps to delay the production of HIV infection and improves the quality of life. Duovir tablets are not a permanent cure for HIV infection. This medication only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. The recommended dose of Duovir medicine is decided by a doctor according to your previous medical condition and response to the treatment. Store this medicine at room temperature and keep it away from direct heat and light.

Interactions
Duovir tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions
Clozapine

Etodolac

Fenofibrate

Methotrexate

Atorvastatin

Disease Interactions
Renal dysfunction

Bone marrow suppression

Myopathy

Alcohol Interaction
Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication
Do not take this medicine if you are allergic to Lamivudine and Zidovudine.

Duovir tablet is not recommended in patients known to be hypersensitive.

This medicine is not recommended for use in patients with severe liver disease.