ABAKAST-L ABACAVIR-LAMIVUDINE 600/300 MG TABLET

Brand name: Abakast-L

Generic name: Abacavir/Lamivudine

Strength: 600 mg/300 mg

Manufacturer: Aprazer

Dosage form: Tablet

Indication: HIV

Storage: Store at room temperature.

Overview
Abakast-L is a co-formulation of two antiretroviral agents known as Abacavir and Lamivudine. It is an anti-HIV medicine belonging to the class of Nucleotide analog reverse transcriptase inhibitors. It is used in the treatment of infection caused by HIV (human immunodeficiency virus) namely HIV-1 and HIV-2. The drug is also prescribed often for the treatment of AIDS (acquired immunodeficiency syndrome).

Usage
Abakast-L is administered as an oral-use tablet once daily (specifically, as per the doctor’s prescription). It should not be taken in doses greater or less than the prescribed strength. Take the Abakast-L tablet with a glass of water at the same time every day. Do not skip or overdose. Use effective contraception during antiretroviral therapy.

Pharmacodynamics
Abacavir (Abakast-L):- It’s an NRTI (nucleoside reverse transcriptase inhibitor) that works against the Human Immunodeficiency Virus Type 1 (HIV-1). It is phosphorylated into active metabolites that compete for viral DNA incorporation. Abacavir functions as a chain terminator of DNA synthesis by competitively inhibiting the HIV reverse transcriptase enzyme.

Lamivudine (Abakast-L):- It is a nucleoside reverse transcriptase inhibitor (NRTI) that inhibits viral DNA synthesis in the Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) viruses. When phosphorylated, it can produce active metabolites that compete with viral DNA for inclusion. Lamivudine metabolites impede the action of the HIV reverse transcriptase enzyme by incorporating DNA.

Interactions
Abakast-L tablets may show significant interactions with the following medications, diseases, and alcohol:

With Medicines

• Bexarotene
• Zalcitabine
• Leflunomide
• Emtricitabine
• Teriflunomide

With Diseases

• Hepatotoxicity
• Pancreatitis
• Renal impairment

With Alcohol

• The interaction of the Abakast-L tablets with alcohol is not known. Please contact your medical team before consuming any drink that contains alcohol.

Contraindications

• Abakast-L tablets are not recommended for use in patients who are:
• Hypersensitive
• Allergic to Abacavir
• Allergic to Lamivudine