TELURA

DESCRIPTION

  • Composition : Tenofovir Disoproxil Fumarate, Lamivudine and Efavirenz
  • Manufacturer: Mylan
  • Indication: Anti HIV
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

  • 300mg
  • 600mg
Category:

Brand Name: Telura
Generic Name: Lamivudine + Tenofovir disoproxil fumarate + Efavirenz
Manufacturer: Mylan
Dosage Form: Tablet
Strength: 300mg/300mg/600mg
Composition: Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg) + Efavirenz (600mg)
Indication: HIV
Packaging: 30 tablet (30 / strip)
Storage: Store at room temperature

Overview
Telura (Lamivudine + Tenofovir disoproxil fumarate + Efavirenz) tablet is a combination of three antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication belongs to a class of medication known as nucleoside reverse transcriptase inhibitors (NRTIs). Telura tablet boosts your immune system to fight against infection and prevents the virus from multiplying. It is important to take this medicine as prescribed by your healthcare provider. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor.

Pharmacodynamics
Lamivudine (Telura):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) to disrupt viral DNA synthesis. It can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.

Tenofovir Disoproxil Fumarate (Telura):- is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. It inhibits the activity of HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA chain termination.

Efavirenz (Telura):- belongs to the NNRTI (non-nucleoside reverse transcriptase inhibitors) class of antiretrovirals. Both nucleoside and non-nucleoside RTIs (reverse transcriptase inhibitors) inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme that transcribes viral RNA into DNA. It is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.

Usage
Telura tablet is a combination of three anti-HIV medicines: Lamivudine, Tenofovir disoproxil fumarate, and Efavirenz. This medication is not a permanent cure for HIV infection. It only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. The recommended dose of Telura medicine is decided by a doctor according to your previous medical condition and response to the treatment. If you experience any signs and symptoms while receiving the Telura tablet, inform your doctor immediately.

Interactions
Telura tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions
Amiodarone

Tobramycin

Fluconazole

Ciprofloxacin

Methotrexate

Aspirin

Cisplatin

Disease Interactions
Hepatoxicity

CNS disorders

Renal dysfunction

Alcohol Interaction
Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication
Do not use this medicine if you are allergic to Lamivudine, Tenofovir disoproxil fumarate, and Efavirenz

Telura tablet is not recommended in patients known to be hypersensitive.

Alternate Brands
Teefavir
Tenof EM

Side Effects
This medicine may cause some common side effects. Discuss the risks and benefits of the Telura tablets with the doctor before starting the treatment.

Common Side Effects
Headache

Tiredness

Loss of weight

Nausea

Insomnia

Diarrhea

Blood in urine

Irregular heartbeat

Abnormal dream

Fever

Chills

Loss of strength

Fatigue

Sore throat

Unusual weakness

Blurred vision

Indigestion

Constipation

Redness of skin

Abdominal pain

Heartburn

Muscle pain

Note – immediately contact your health care provider if any side effects occur.

Dosage
Take this medicine as prescribed by your doctor. Make sure to not skip or stop your regular dosing schedule.

Missed Dose
It is advisable not to miss a dose. If you miss a scheduled dose of Telura tablets, contact your doctor immediately.

Overdose
In case of an overdose of Telura tablets, the doctor will provide emergency medical treatment.

Warnings
Before starting treatment with Telura medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.

Contraception

Use suitable methods of contraception to prevent pregnancy while taking Telura medicine.

Children and adolescents

Telura tablets are not recommended for use in children under the age of 18.

Warnings For Female
Pregnancy

Do not use Telura medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.

Breastfeeding

This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Telura (Lamivudine + Tenofovir disoproxil fumarate + Efavirenz).

Precautions
Close monitoring of body fat distribution and body weight is required during treatment with this medicine.

This medication should be used with caution in some patients because it may increase the risk of CNS side effects like drowsiness, hallucinations, etc.

Telura tablet may increase the risk of lactic acidosis.

This medication may increase the risk of immune reconstitution syndrome.

Cautions
Do not drive or operate heavy machinery.

Do not crush or break the tablet.

Not safe for pregnant women.

Do not breastfeed while receiving this medication.

DESCRIPTION

  • Composition : Tenofovir Disoproxil Fumarate, Lamivudine and Efavirenz
  • Manufacturer: Mylan
  • Indication: Anti HIV
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

  • 300mg
  • 600mg
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