CERITINIB 150MG CAPSULE (SPEXIB)

CERITINIB 150MG CAPSULE (SPEXIB)

DESCRIPTION

PACKAGE

Overview and Usage

Brand name: Spexib

Generic name: Ceritinib

Strength: 150mg,450mg

Manufacturer: Novartis India Ltd

Dosage form: Capsule

Indication: Non-small cell lung cancer

Storage: Store at room temperature

Overview

Spexib is an anticancer formulation. Ceritinib is a prescription medicine used in the treatment of Non-small cell lung cancer (NSCLC). It is available in the form of capsules with a strength of 150mg. Ceritinib 150mg Capsule belongs to a class of medicines known as protein kinase inhibitors. The Spexib (Ceritinib) capsule works by blocking the activity of an abnormal protein that helps the cancer cells multiply in the body.

How Does Ceritinib 150mg Capsule Work?

Ceritinib is the active ingredient of Spexib. Ceritinib 150mg Capsule works by inhibiting Anaplastic lymphoma kinase (ALK), also called ALK tyrosine kinase receptor or simply CD246 (cluster of differentiation 246). Nearly 4-5% of NSCLCs comprise a chromosomal rearrangement that is responsible for the generation of a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), leading to constitutive kinase activity that further contributes to carcinogenesis and is thought to drive the malignant phenotype. The compound exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. Ceritinib inhibited the clinical proliferation of cell lines expressing EML4-ALK and NPM-ALK fusion proteins and showed dose-dependent inhibition of EML4-ALK-positive NSCLC xenograft growth in mice and rats.

Usage Of Ceritinib 150mg Capsule

Ceritinib 150mg Capsule is an anticancer drug for patients suffering from Non-small cell lung cancer. In patients below the age of 18 years, Ceritinib Capsule is not indicated. It is not safe for use in pregnant and nursing women. Ceritinib 150mg Capsule should be taken as per the prescription by the health professional and should not be discontinued until recommended. It is important to know the side effects of this medicine before starting its course.

Interactions

Ceritinib 150mg Capsule may interact with certain other drugs and diseases. Before consuming the capsules, it is important to know the interactions of the medicine. Here are some of the medicines and diseases with which this medicine may interact severely.

With Medicines

  • Efavirenz
  • Ketoconazole
  • Ondansetron
  • Vasopressin
  • Sorafenib

With Diseases

  • Heart rhythm disorders
  • Gastrointestinal disease
  • Lung Toxicity
  • Pancreatitis
  • Liver Disease
  • Kidney Disease

With Alcohol

  • The interaction of alcohol is not yet known. Consult your healthcare professional.

Contraindications

Ceritinib 150mg Capsule is not indicated for use in the following cases:-

  • Hypersensitivity
  • Allergy to Ceritinib
  • Allergy to any inactive ingredient of Spexib

Side Effects

Some common side effects of Ceritinib 150mg Capsule are listed below:-

  • Blurred vision
  • Diarrhea
  • Loss of appetite
  • Abdominal pain
  • Skin Rash
  • Low blood pressure
  • Weight loss
  • Fever
  • Chills
  • Nausea
  • Vomiting
  • Tiredness or weakness
  • Difficulty in breathing
  • Irregular heartbeat
  • High blood pressure
  • Pale skin
  • Anemia
  • High blood sugar
  • Seizures
  • Dizziness
  • Shortness of breath
  • Muscle pain
  • Dark urine
  • Bleeding
  • Numbness
  • Tingling sensation

Note:- It is advisable to contact a healthcare professional if side effects occur and last longer than usual.

Dosage

Normal Dose

Take Ceritinib 150mg Capsule orally as per the prescription by your healthcare professional. Do not increase or decrease the dose strength or stop taking this medication without consulting a qualified medical practitioner.

Missed Dose

If you miss a dose of this medicine, call your physician right away to learn the ways of coping with the skipped dose.

Overdose

In case of an overdose, the patient is advised to consult a health professional immediately if any unusual symptoms occur.

Warnings

Warnings For Females

  • Pregnancy
    • Ceritinib 150mg Capsules are not indicated for use in pregnant women.
  • Breastfeeding
    • Spexib (Ceritinib) capsules may not be safe for use in women who are breastfeeding.

Cautions

  • Do not cut or bite the capsules.
  • Do not drive after taking the capsules.
  • Do not skip a dose.
  • Do not overdose.
  • Do not operate machinery after taking the capsules.

Precautions

    • Contraception
      • Use proper contraception during the course of Ceritinib 150mg Capsule to avoid pregnancy.
    • Allergy
      • Do not consume the tablets if you have a serious allergy to their components.
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