Overview and Usage
Brand name: Spexib
Generic name: Ceritinib
Manufacturer: Novartis India Ltd
Dosage form: Capsule
Indication: Non-small cell lung cancer
Storage: Store at room temperature
Spexib is an anticancer formulation. Ceritinib is a prescription medicine used in the treatment of Non-small cell lung cancer (NSCLC). It is available in the form of capsules with a strength of 150mg. Ceritinib 150mg Capsule belongs to a class of medicines known as protein kinase inhibitors. The Spexib (Ceritinib) capsule works by blocking the activity of an abnormal protein that helps the cancer cells multiply in the body.
How Does Ceritinib 150mg Capsule Work?
Ceritinib is the active ingredient of Spexib. Ceritinib 150mg Capsule works by inhibiting Anaplastic lymphoma kinase (ALK), also called ALK tyrosine kinase receptor or simply CD246 (cluster of differentiation 246). Nearly 4-5% of NSCLCs comprise a chromosomal rearrangement that is responsible for the generation of a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), leading to constitutive kinase activity that further contributes to carcinogenesis and is thought to drive the malignant phenotype. The compound exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. Ceritinib inhibited the clinical proliferation of cell lines expressing EML4-ALK and NPM-ALK fusion proteins and showed dose-dependent inhibition of EML4-ALK-positive NSCLC xenograft growth in mice and rats.
Usage Of Ceritinib 150mg Capsule
Ceritinib 150mg Capsule is an anticancer drug for patients suffering from Non-small cell lung cancer. In patients below the age of 18 years, Ceritinib Capsule is not indicated. It is not safe for use in pregnant and nursing women. Ceritinib 150mg Capsule should be taken as per the prescription by the health professional and should not be discontinued until recommended. It is important to know the side effects of this medicine before starting its course.
Ceritinib 150mg Capsule may interact with certain other drugs and diseases. Before consuming the capsules, it is important to know the interactions of the medicine. Here are some of the medicines and diseases with which this medicine may interact severely.
- Heart rhythm disorders
- Gastrointestinal disease
- Lung Toxicity
- Liver Disease
- Kidney Disease
- The interaction of alcohol is not yet known. Consult your healthcare professional.
Ceritinib 150mg Capsule is not indicated for use in the following cases:-
- Allergy to Ceritinib
- Allergy to any inactive ingredient of Spexib