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Brand Name :- Cyramza

Generic Name :- Ramucirumab

Manufacturer:- Lilly

Dosage Form:- Injection

Strength :- 500mg/50ml

Composition :- Ramucirumab

Packaging:- 1vial

Indication:- Stomach cancer, non-small cell lung cancer, colorectal cancer.

Storage conditions:- Protect from light. Do not shake or freeze the vial.


Cyramza (ramucirumab) is a medicine used to treat stomach cancer (that got worse during or after a certain type of chemotherapy), colorectal cancer, and non-small cell lung cancer that has spread to other parts of the body. This medication interferes with the growth of cancer cells in the body. This medication comes in the form of an injection and it is given as an infusion every 2 to 3 weeks by your doctor or nurse. This medicine works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.

Pharmacodynamics Of Cyramza (Ramucirumab) 

Ramucirumab is a VEGFR2 antagonist that specifically binds VEGFR2 and blocks the binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. A dose range of 6-12mg is administered every two or three weeks. Ramucirumab systematic exposure increased dose proportionally at doses of 8mg and above and steady-state concentrations were achieved at approximately 12 weeks.

Side Effects Of Cyramza (Ramucirumab) 

This medicine may cause some unwanted side effects. If they occur it may require medical attention.

 Common Side Effects 

  • Fainting
  • Nausea
  • Constipation
  • Fever
  • Chills
  • Vomiting
  • Dizziness
  • Shortness of breath
  • Chest pain
  • Diarrhea
  • Burning
  • Itching
  • Swelling
  • Weakness
  • Shivering
  • Sweating
  • Pain on the palms of your hand
  • Muscle cramps
  • Low white blood cell count
  • Not feeling hungry
  • Low sodium in the blood
  • Nose bleeds
  • Back pain

Serious Side Effects 

  • Increase in blood pressure
  • Severe bleeding
  • Abdominal pain
  • Bloody urine
  • Coughing up blood
  • Lightheadedness
  • Change in vision
  • Slow wound healing
  • Signs of kidney problems

Note – Always inform your doctor, if you experience any unusual symptoms   


This medication is given by slow injection into a vein by a doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.

Missed Dose 

  • In case you missed a dose, immediately contact your doctor.


  • Emergency medical treatment is required, in case of an overdose.

Usage Of Cyramza (Ramucirumab) 

This medication is used to treat stomach cancer, and non-small cell lung cancer and it is also approved to treat colorectal cancer. It is also approved for use in combination with docetaxel to treat patients with metastatic non-small cell lung cancer. This medication is given by slow injection into a vein by a doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.


General Warnings And Precautions 

  • Cyramza increases the risk of hemorrhage.
  • This medication increases the risk of gastrointestinal perforations.
  • Impaired wound healing can occur in patients who receive drugs that inhibit VEGF and VEGFR pathways.
  • Infusion-related observed reactions include – back pains, chest pain, chills, etc.
  • Before using this medication tell your doctor about your medical history of kidney disease, high blood pressure, and liver disease.

Cautionary Labels  

  • Increases risk of bleeding
  • Close monitoring is necessary
  • Not safe for pregnant women