INLYBEST-1

OVERVIEW & USAGE

Brand name- Rolimus

Generics- Everolimus

Manufacturer- Cipla Ltd.

Dosage form- Tablet

Route of Administration- oral

Strength- 5, 10mg

Composition- Everolimus

Packaging- Strip (30 Tablets)

Indication- Immunosuppressant for breast cancer, pancreatic cancer, lung cancer, and kidney cancer.

Storage- Store at room temperature (10-30°C)

Class of drug- Anti-neoplastic (Macrolide Lactams)

Mechanism Of Action

It belongs to a class of medications called kinase inhibitors. Rolimus treats cancer by inhibiting cancer cells from growing further and by decreasing blood supply to the cancer cells. Rolimus prevents transplant rejection by decreasing the activity of the immune system.

Side Effects-

Weakness, Sinus inflammation, Infection, Fever, Cough, Fatigue, Stomatitis (Inflammation of the mouth), Otitis media (infection of the ear), Diarrhea, and Upper respiratory tract infection (UTI).

Pharmacodynamics

It is the study of drug effects and what the medicine does to the body.

Rolimus binds with high affinity to the FK506 binding protein-12 (FKBP-12), thereby forming a drug complex that stops the activation of mTOR. This inhibition reduces the activity of growth stages in cancer cells and subsequently induces cell growth arrest and apoptosis.

Pharmacokinetics

Study of what the body does to the medicine. Rolimus is absorbed rapidly and reaches peak concentration after 1.3-1.8 hours. A steady state is reached within 7 days.

Minimum effect concentration (MEC)

A minimum concentration of medicine in the blood is required to produce the therapeutic effects. Its predefined therapeutic MEC is ( 3 ng/mL)

Minimum toxic concentration (MTC)

Minimum medicine concentration in blood above which toxic or adverse effects are precipitated. Its MTC is 8ng/mL

Bioavailability Rate

After oral administration, the medicine achieved approximately 20% bioavailability.

Shelf Life

Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at the time of manufacture.

Its shelf life is 2years

Usage

Which disease area

Breast cancer, pancreatic cancer, lung cancer, and kidney cancer.

Substitutes

Volantis 10mg Tablet-  Dr Reddy’s Laboratories Ltd

Evertor 10mg Tablet- Biocon Ltd

Afinitor 10mg Tablet- Novartis India Ltd

Alternate Brands

Everbliss 10mg Tablet- BDR Pharmaceuticals Internationals Pvt

Evercan 10mg Tablet- Miracalus Pharma Pvt Ltd

Rapact 10mg Tablet- Natco Pharma Ltd

Evelimus 10mg Tablet- Emcure Pharmaceuticals Ltd

Everotas 10mg Tablet- Intas Pharmaceuticals Ltd

Brand name: Inlybest-1

Generic name: Axitinib

Strength: 1mg and 5mg

Manufacturer: Aprazer

Dosage form: Tablet

Indication: Kidney cancer

Storage: Store at room temperature.

Overview

Inlybest-1 contains Axitinib as an active substance and it is indicated for the treatment of renal cell carcinoma (a type of cancer that begins in the kidney). This anticancer formulation belongs to a group of medications known as tyrosine kinase inhibitors. Inlybest-1 is available in the form of a tablet and it works by blocking the action of an abnormal protein. Take this medicinal formulation orally and swallow the whole tablet with a glass of water. Follow your dosing instructions as prescribed by your general practitioner.

Pharmacodynamics

Axitinib helps prevent the progression of cancer by inhibiting angiogenesis and blocking tumor growth. It selectively blocks the tyrosine kinase receptors VEGFR-1 (vascular endothelial growth factor receptor), VEGFR-2, and VEGFR-3. The formulation is mainly eliminated in the feces (about 41%) with nearly 12% of the original dose as unchanged axitinib. There is also 23% eliminated in the urine, most of which are metabolites.

Usage

This effective regimen is used to treat Kidney cancer and it helps in decreasing the spread of cancerous cells. Follow all the instructions carefully and administer the tablet as directed by your physician. Do not increase or decrease the strength of Inlybest-1 and for better efficacy complete your dosing schedule. Monitoring of blood pressure is required during treatment with Inlybest-1 (Axitinib) tablets.

Interactions

It is important to know the interactions of Inlybest-1 tablets with other drugs and diseases, before starting therapy with this ant-cancer formulation.

Medicine Interactions

• Carbamazepine
• Etravirine
• Leflunomide
• Rifampin
• Thalidomide
• Lorlatinib

Disease Interactions

• Hemorrhagic events
• Cardiac failure
• GI perforation
• Hypertension
• Proteinuria
• Thyroid dysfunction
• Lung toxicity

Alcohol Interactions

• Avoid consuming alcohol while receiving treatment with Inlybest-1 tablets.

Contraindications

The Inlybest-1 tablet is not indicated for use in the below-mentioned cases. Do not use this medication if any of the following apply to you:-

• Hypersensitive to the active ingredients present in the medication.
• Allergic to Axitinib.