SOLIRIS 300MG INJECTION (ECULIZUMAB)

SOLIRIS 300MG INJECTION (ECULIZUMAB)

DESCRIPTION

  • Composition: Eculizumab
  • Manufacturer: Alexion Pharmaceuticals
  • Indication: Blood cancer
  • Packaging: Vial
  • Dosage Form: Injection

PACKAGE

  • 300mg

Soliris is a formulation of Eculizumab, a humanized monoclonal antibody. This medicine is used in the treatment of patients diagnosed with myasthenia gravis. This disease is a long-term neuromuscular condition. Eculizumab is also used in the prevention of red blood cell breakdown. It is indicated to patients weighing above 5 kilograms (11 pounds) to treat various blood disorders. Soliris (Eculizumab) is available in the strength of 300mg as injections for intravenous (IV) use only.

Pharmacodynamics
Soliris comprises Eculizumab as its active salt. It is a monoclonal antibody that inhibits the cleavage of complement protein C5 into C5a and C5b, as well as the development of the terminal complement complex C5b-9. Complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria, complement-mediated microangiopathy in atypical hemolytic uremic syndrome, and immune-mediated inflammation and central nervous system damage in neuromyelitis optica spectrum disorder are all prevented by inhibiting this complex.

Interactions
The following are some interactions of Soliris (Eculizumab) injection with other drugs and diseases. You may require dose modifications.

With Medicines

  • Immune globulin
  • Efgartigimod alfa

With Diseases

  • Meningococcal infections
  • Infections
  • Progressive multifocal leukoencephalopathy
  • Thrombotic microangiopathy

With Alcohol

Soliris (Eculizumab) injection may interact with alcoholic drinks. This may lead to severe effects. Thus, it’s advisable to avoid alcohol consumption.

Contraindications
Soliris (Eculizumab) injection is not indicated for use in the following conditions.

  • Hypersensitivity
  • Allergy to Eculizumab
  • Pregnancy
  • Breastfeeding

Side Effects Of Soliris 300mg Injection

The following are some side effects of Soliris (Eculizumab) injection. Contact your doctor if these events occur for too long or become severe.

  • Bone pain
  • Hoarseness
  • Constipation
  • Ear congestion
  • Sneezing
  • Chills
  • Nausea
  • Pale skin
  • Loss of appetite
  • Difficulty in breathing
  • Loss of voice
  • Pounding in the ears
  • Nervousness
  • Cough
  • Sore throat
  • Fast heartbeat
  • Fever
  • Headache
  • Vomiting
  • Tarry stools
  • Bladder pain

Soliris (Eculizumab) injection is not indicated for self-use. You can’t take this drug on your own. Your doctor will administer the Soliris injection as per a fixed strength. It must be given intravenously (into a vein) after dilution.

Missed Dose
If you skip a dose of Soliris (Eculizumab) injection, you must ask your doctor about the best ways to cope with it. Your therapy may require rescheduling.

Overdose
If you overdose on Soliris (Eculizumab) injection, you may experience symptoms like dizziness, fainting, and shortness of breath. Other symptoms may also arise. Consult your doctor immediately.

General Warnings
Inform your doctor about the medicines you already take. You may require dose adjustments concerning your medical record.
Soliris (Eculizumab) injection may interact with alcoholic drinks. Thus, it’s advisable to avoid alcohol consumption.
During your therapy with this drug, you may develop bacterial infections. Tell your doctor about any new symptoms without delay.
You may require certain blood tests to monitor the condition and look out for improvements.

Warnings For Females

  • Pregnancy
    During pregnancy, the use of Soliris (Eculizumab) injection may be unsafe. Consult your doctor to know the risks and benefits of this drug.
  • Breastfeeding
    During breastfeeding, the use of Soliris (Eculizumab) injection may be unsafe. Either discontinue breastfeeding or know the benefits and risks of this drug.

Cautions

  • Do not try to self-administer this drug.
  • This medicine may cause dizziness and loss of concentration. It’s advised to avoid driving.
  • Keep Soliris (Eculizumab) injections away from children and pets.
  • Do not overdose or skip a dose during Soliris therapy.

DESCRIPTION

  • Composition: Eculizumab
  • Manufacturer: Alexion Pharmaceuticals
  • Indication: Blood cancer
  • Packaging: Vial
  • Dosage Form: Injection

PACKAGE

  • 300mg
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