Brand Name: Stivarga

Generic Name: Regorafenib

Manufacturer: Bayer Pharma

Dosage Form: Tablet

Strength: 40mg

Composition: Regorafenib

Packaging: 28 tablets (28/strip)

Indication: Colorectal and Liver cancer

Storage: Store at room temperature


Stivarga (Regorafenib) tablet is used in the treatment of liver cancer and colorectal cancer. This tablet works by blocking the action of an abnormal protein that multiplies the cancer cells. It is also used to treat a type of tumor that can affect the stomach, esophagus, or intestines. Do not take this medicine in the wrong way as it may lead to some severe side effects. It is advisable not to change or stop the dose without taking suggestions from your doctor. If you experience any symptoms while receiving this medicine, inform your doctor immediately. Store this medicine at room temperature and keep it away from light and moisture.

Pharmacodynamics Of Stivarga

Stivarga is a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment. Stivarga 40 mg tablet has demonstrated anti-angiogenic activity in a rat tumor model and inhibition of tumor growth as well as anti-metastatic activity in several mouse xenograft models including some for human colorectal carcinoma.

Usage Of Stivarga

Stivarga (Regorafenib) tablet is used to treat metastatic colorectal cancer and a type of liver cancer called hepatocellular carcinoma. This medicine works by stopping the growth of cancer cells. Take this medicine with or without food at the same time every day. Do not miss your regular dosing schedule. The recommended dose is decided by a doctor according to your previous medical condition and response to the treatment. Regular blood tests are required during treatment with this medicine. Do not crush or break the tablet and swallow the whole tablet with a glass of water.

Substitutes Of Stivarga

  • Resihance
  • Regonat
  • Nublexa

 Side Effects Of Stivarga

This medicine may cause some mild or severe side effects. Discuss the risks and benefits of this medication with the doctor before starting the treatment.

Common Side Effects

  • Vomiting
  • Infection
  • Weakness
  • Nausea
  • Anxiety
  • Weight loss
  • Swelling
  • Pounding in ears
  • Sore throat
  • Loss of appetite
  • Dizziness
  • Headache
  • Anemia
  • High blood pressure
  • Low blood platelets
  • Diarrhea
  • Blurred vision
  • Chest pain
  • Indigestion
  • Bleeding gums
  • Stomatitis
  • Mucosal inflammation
  • Rash
  • Dry skin
  • Coughing up blood
  • Fatigue
  • Shortness of breath
  • Nose bleeds
  • Difficulty in speaking
  • Dark-colored urine
  • Pain
  • Hair loss
  • Chills
  • Pale skin
  • Loss of strength

Note- immediately contact your doctor if any side effects occur.

Dosage Of Stivarga

Take this medicine as prescribed by your doctor. Do not skip or miss your dosing schedule.

Missed Dose

  •  It is advisable not to miss a dose. If you miss a scheduled dose of this medicine, contact your doctor immediately.


  • In case of an overdose, the doctor will provide emergency medical treatment.

Warnings Of Stivarga

Before starting treatment with the Stivarga tablets, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.


  • Use effective methods of contraception to prevent pregnancy while taking this medicine.
  • Children and adolescents
  • This medicine is not advisable for use in children and adolescents.

Warnings For Female


  • Do not use the Stivarga tablets if you are pregnant or planning to become pregnant. Avoid this medication at the time of pregnancy.


  • This medicine is not recommended for breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication.

Precautions Of Stivarga

  • Stivarga tablets may increase the risk of bleeding.
  • Regular monitoring of blood pressure is required while receiving this medicine.
  • This medication makes your immune system weak, which increases the risk of infections.
  • Dose alteration is required for patients who have a history of heart disease.
  • Inform your doctor if you experience any side effects like diarrhea, weight loss, anemia, high blood pressure, and vomiting.
  • Avoid contact with people who have infections.

Cautions Of Stivarga

  • Do not drive or operate heavy machinery.
  • Not safe for pregnant women.
  • Do not breastfeed while receiving this medication.
  • Do not crush or break the tablet.