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Brand name – Xovoltib

Generic name – Afatinib

Manufacturer – Boehringer Ingelhein

Strength – 40mg/30mg

Dosage Form – Tablet

Composition – Afatinib

Indication – Lung Cancer

Storage – at room temperature



Xovoltib is a chemotherapy medicine that is used to treat non-small cell lung cancer. Afatinib is the generic name of this medication. It is a 4-anilinoquinazoline tyrosine kinase that has antineoplastic activities.


Xovoltib is used as a first-line treatment for non-small cell lung cancer which has EGFR mutations. EGFR stands for epidermal growth factor receptor. Some mutations that occur in EGFR stimulate cell proliferation in lung cancer. Xovoltib binds irreversibly to EGFR and as a result, down-regulates its signals. It furthermore stops cell proliferation and shrinking of the tumors. In addition, it blocks phosphorylation and triggers cell death in the cancer cells.


Xovoltib 40mg tablets or 30 mg tablets are given based on a prescription by the doctor or healthcare provider for the treatment of non-small cell lung cancer (NSCLC). The course and dosage of the medication are decided by the doctor depending on the stage of cancer and the condition of the patient. Xovoltib is an oral tablet that needs to be taken on an empty stomach either one hour before the meal or two hours after the meal. Also, it is advisable to inform the doctor about all the past ailments and allergies before starting the treatment.


With medicines

Xovoltib 40mg (30mg) can interact with some other prescription and non-prescription medicines and interfere with each other’s workings or increase the side effects. Inform your doctor if you consume any of these –

  • Itraconazole
  • Cyclosporine
  • Erythromycin
  • Carbamazepine
  • Phenytoin
  • Rifampin
  • Phenobarbital

With disease

Some diseases may show interactions with. Hence, consult your doctor if you have any of these conditions –

  • Lung problems
  • Eyes problems
  • Cardiovascular conditions
  • Renal problems
  • Liver diseases

With alcohol

Interactions of alcohol with Xovoltib are unknown. So, it is advisable to avoid consuming alcohol during the treatment.

Contraindication Off Xovoltib

Xovoltib 40mg tablets or Xovoltib 30mg should not be prescribed to patients who show an allergic reaction.

Alternate Brands

  • Giotrif
  • Afanat

Side Effects

  • Dry skin
  • Loss of appetite
  • Cracked or swollen lips
  • Acne
  • Nose bleeds
  • Diarrhea
  • Nausea
  • Vomiting
  • Fever
  • Cough
  • Nose bleeds
  • Weight gain
  • Blisters of skin
  • Rashes due to sun exposure
  • Dark coloration of urine
  • Shortness of breath
  • Eye pain
  • Increased bruises
  • Irregular heart rate
  • Nail infection
  • Sensitivity to light
  • Yellowing of skin and eyes
  • Painful urination


It is prescribed by the doctor hence, it is advisable to follow the prescription given. Xovoltib 40mg tablets are taken orally once every day on an empty stomach.

Missed dose

It is advisable to avoid missing any doses. In case you miss a dose of Xovoltib 40mg (30mg) consult your doctor immediately.


In case of an overdose, contact your doctor or any healthcare provider and seek medical attention immediately. Dizziness, headaches, and vomiting are some of the initial signs of an overdose.

  • Xovoltib tablets can cause an allergic reaction in some patients. Hence, it is mandatory to read complete information about the tablets before consuming them.
  • Inform the doctor about the vitamin supplements, herbal medications, and prescription and non-prescription drugs.  Some of the medications that can interact are – antifungal, seizures, and HIV medications.
  • Xovoltib 30mg can harm the fetus hence, it is advisable to avoid pregnancy during and till two weeks after the last dose.
  • The treatment with Xovoltib tablets increases the sensitivity of the skin therefore it is advisable to avoid sunlight or wear complete covering and sunscreen
  • Also, avoid breastfeeding while you are taking Xovoltib tablets
  • Avoid driving and operating heavy machinery and also avoid drinking alcohol during the treatment.
  • Inform the doctor about the past health conditions –
  • Lung problems
  • Eyes problems (dry eyes or if you wear contacts)
  • Heart conditions
  • Kidney problems
  • Liver diseases