Brand name – Trastuzumab (Herceptin)

Generic name – Trastuzumab

Manufacturer – Roche

Strength – 440mg

Dosage Form – Injection

Composition – Trastuzumab

Indication – Breast Cancer

Storage – 2° – 8° C

Overview Of Trastuzumab 440mg Injection

Trastuzumab 440mg injection is a target therapy medication that is used in the treatment of breast cancer. It is also used in the treatment of gastric cancers. It is a monoclonal human epidermal growth factor receptor 2 (HER-2) antibody. Trastuzumab 440mg injection is an intravenous injection that is injected by a doctor or a trained nurse.


The upregulation of HER-2 in cancer cells causes abnormal cell proliferation therefore Trastuzumab binds to these receptors. As a result, Trastuzumab stops the uncontrollable growth of the cancerous cells. In addition, it also initiates antibody-dependent cell-mediated cytotoxicity by using immune cells like natural killer cells.

Side Effects

  • Heartburn
  • Acne
  • Hot flashes
  • Constipation
  • Diarrhea
  • Loss of appetite
  • Changes in nails
  • Trouble in sleeping
  • Fatigue
  • Sore throat
  • Fever
  • Seizures
  • Dark coloration in urine
  • Nosebleeds
  • Increased heartbeats
  • Numbness of hands and feet


Trastuzumab 440mg injection is a prescription-based medication that is given intravenously by a doctor or an experienced nurse.

Missed dose

It is advisable to avoid missing any doses of Trastuzumab but in case you miss a dose consult your doctor immediately.


In case of an overdose of Trastuzumab 440mg, contact your doctor or any healthcare provider and seek medical attention immediately.


  • Trastuzumab can cause an allergic reaction in some patients hence it is necessary to read the complete composition list.
  • Inform the doctor about all the vitamin supplements, herbal medications, and prescription and non-prescription drugs since Trastuzumab can interact with them.
  • It is advisable to avoid pregnancy and breastfeeding during the treatment as Trastuzumab can affect the fetus.
  • Avoiding alcohol consumption, driving, and operating heavy machinery while injecting Trastuzumab 440mg injection.
  • Inform the doctor about past medical conditions – thrombocytopenia, peripheral neuropathy, cardiovascular conditions.