SOFOSBUVIR 400MG TABLET (SOFOVIR)

SOFOSBUVIR 400MG TABLET (SOFOVIR)

DESCRIPTION

  • Composition : Sofosbuvir
  • Manufacturer: Hetero Drugs Ltd.
  • Indication: Chronic hepatitis C virus (HCV) infection
  • Packaging: bottle of 28 tablets
  • Dosage Form: Tablet

PACKAGE

  • 400mg
  • 100mg

Medicine Details

Brand name – Sofovir
Generic name – Sofosbuvir
Manufacturer – Hetero Drugs Ltd.
Salt composition – Sofosbuvir 400mg
Storage – Store at room temperature (10-30°C)
Dosage form – Oral (tablet)
Strength – 400mg
Packaging – Bottle of 28 tablets
Gender – Unisex
Prescription required – Yes
Indication – used in the treatment of chronic hepatitis C virus (HCV) infection

Description
Sofovir (Sofosbuvir 400mg) is used with other medications in the treatment of chronic (long-lasting) hepatitis C virus (HCV) infection in adults. It is an antiviral medicine that lowers the amount of virus in the body and works to eliminate the virus over a period of time.

Pharmacodynamics
Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half life of Sofosbuvir is 0.4 hours, and the half life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in urine, 2.5% in expired air recovery and 14% in feces.

Ingredients
The active ingredient of Sofovir tablets is Sofosbuvir 400mg.

Usage Of Medicine
Sofovir (Sofosbuvir) 400mg tablet is an antiviral medicine. It is used with other medicines to treat chronic (long-lasting) hepatitis C virus (HCV) infection in adults.

Side Effects Of Sofosbuvir 400mg Tablet

Common Side Effects

  • Fever
  • Chills
  • Fatigue
  • Headache
  • Loss of appetite
  • Weakness
  • Skin rash
  • Itching
  • Irritability
  • Joint pain

Serious Side Effects

  • Anemia
  • Insomnia
  • Nausea
  • Fainting
  • Neutropenia (low white blood cell count)

Dosage
Normal Dose
Do not crush, chew or break the tablet. Take the same dose as prescribed by your healthcare provider.

Missed Dose
In case of a missed dose, take the medicine as soon as you remember. However, if it is already the time for the next dose, do not take the previous dose. Skip it and take the scheduled dose. Also, tell your healthcare provider about the same.

Overdose
Please seek emergency medical attention.

Be sure to tell your healthcare provider about your medical history and the list of medications you already take.

Avoid the consumption of alcohol, fatty and sugary foods.

During pregnancy, make sure to ask your healthcare provider before the consumption of Sofovir 400mg tablets.

Sofovir 40mg (Sofosbuvir) is safe for consumption, only if prescribed by the doctor. Therefore, ask your healthcare provider about the consumption of this medicine during breastfeeding.

In patients with liver or kidney disease, Sofovir should be administered with caution.

Avoid driving and operating heavy machines, if you feel unwell after taking Sofovir 400mg tablet.

Do not alter or increase the dose strength, unless your healthcare provider tells you.

Do not stop taking Sofovir, unless your healthcare provider tells you.

DESCRIPTION

  • Composition : Sofosbuvir
  • Manufacturer: Hetero Drugs Ltd.
  • Indication: Chronic hepatitis C virus (HCV) infection
  • Packaging: bottle of 28 tablets
  • Dosage Form: Tablet

PACKAGE

  • 400mg
  • 100mg
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