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Brand name :- Opdivo

Generic name :- Nivolumab

Manufacturer :- Bristol-myers Squibb pharma

Dosage form :- Injection

Strength :- 40mg/4ml

Composition :- Nivolumab

Packaging size :- 1 vial

Indication:- Head and neck cancer, kidney cancer, lung cancer, liver cancer, skin cancer.

Storage conditions:- Store in a cool and dry place.


Opdivo (Nivolumab 100mg) is a prescription medicine used to treat people with certain cancers (lung cancer, liver cancer, skin cancer, head and neck cancer). This medication is also used to treat people with a type of advanced-stage lung cancer that has spread or grown and you have tried chemotherapy and it did not work.

Pharmacodynamics Of Opdivo Injection 

A dose ranges from 0.1mg to 20mg administered as a single dose or multiple doses of opdivo (nivolumab) as a 60 minutes intravenous infusion every 2 to 3 weeks. The predicted exposure of opdivo after a 30 minutes infusion is comparable to 60 minutes infusion.

Opdivo (Nivolumab 100mg Injection) Indications 

  • It is indicated for metastatic small cell lung cancer in patients with progression after platinum-based chemotherapy.
  • Indicated for patients with poor-risk, previously untreated advanced renal cell carcinoma.
  • Indicated for melanoma in patients with lymph node involvement.

Side Effect Of Opdivo (Nivolumab 100mg Injection)

The use of this drug may cause some unwanted effects.

Common Side Effect Of Opdivo 

  • Nausea
  • Skin rash
  • Fatigue
  • Constipation
  • Diarrhea
  • Vomiting
  • Cough
  • Muscle pain
  • Decreased appetite
  • Shortness of breath
  • Fever
  • Swelling
  • Joint pain
  • Chest pain
  • Headache
  • Low amount of sodium in the blood
  • Low energy

Note:- immediately contact your doctor if any of these side effects occur.

Rare Side Effect Of Opdivo 

  • Dehydration
  • Anemia
  • Bleeding from lungs
  • A facial nerve disorder
  • Lung tissue problem
  • Arthritis
  • High blood pressure
  • Stomatitis, a condition with painful swelling and sores inside the mouth.
  • Blurry vision or double vision
  • Eye pain or redness


Usage Of Opdivo (Nivolumab 100mg Injection)

Opdivo (Nivolumab 100mg) medicine is used to treat people with a type of skin cancer called melanoma that has spread or cannot be removed by surgery. It is also used when your head and neck, bladder, small- cell lung cancer has come back or spread and you have tried chemotherapy that contains platinum and it did not work or no longer is working.

Warnings And Precautions 

  • Immune-mediated adverse reactions ( diarrhea, pneumonitis, renal dysfunction) which may be severe, can occur in any organ system or tissue.
  • Monitor for signs and symptoms of adrenal insufficiency during and after treatment.
  • Severe infusion-related reactions can occur.
  • May cause harm when administered to pregnant females.
  • When used in combination with ipilimumab, refer to prescribing information for additional risk information that applies to the combination use treatment.
  • May cause type 1 diabetes.

Cautionary Labels 

  • May harm the immune system
  • Do not drive after taking this medication
  • Not safe for pregnant women
  • Do not take this medication without a doctor advice