IMATIB

DESCRIPTION

  • Composition: Imatinib mesylate
  • Manufacturer: Cipla
  • Indication: Blood cancer
  • Packaging: Strip
  • Dosage Form: Tablet

PACKAGE

  • 100mg
  • 400mg

Brand Name: Imatib

Generic Name: Imatinib mesylate

Manufacturer: Cipla

Dosage Form: Tablets

Strength: 100mg and 400mg

Composition: Imatinib mesylate

Indication: Blood cancer

Packaging: 10 tablets in a strip

Storage: Store at room temperature

OVERVIEW
Imatib (Imatinib mesylate) tablet is used in the treatment of blood cancer. This medicine belongs

to a class of drugs known as tyrosine kinase inhibitors. The Imatib tablet works by stopping the

growth of cancer cells and also prevents the multiplication of cancerous cells. It is important to

take this medicine as prescribed by your doctor. The recommended dose of Imatib tablet is

decided by a doctor according to your previous medical condition and response to the

treatment. Regular monitoring of blood cell count and liver function is required while having

treatment with this medicine. Do not stop the use of Imatib tablets without consulting with your

doctor. If you experience any signs and symptoms while receiving this medicine, inform your

doctor immediately.

Pharmacodynamics
Imatinib Mesylate is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine

kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome

abnormality in CML. It inhibits proliferation and induces apoptosis in BCR-ABL-positive cell lines

as well as fresh leukemic cells from Philadelphia chromosome-positive chronic myeloid

leukemia.

Interactions
Imatib tablets can interact with other medications and it may increase the risk for side effects.

Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions
● Baricitinib

● Carbamazepine

● Warfarin

● Pimozide

● Etanercept

● Leflunomide

Disease Interactions
● Bone marrow suppression

● Fluid retention

● Liver impairment

● Cardiovascular disease

● Kidney impairment

Alcohol Interaction
● Interaction with alcohol is unknown. Please consult your doctor before consuming

alcohol.

Contraindications
● Do not take this medicine if you are allergic to Imatinib mesylate.

● Imatib (Imatinib mesylate) medicine is not recommended in patients known to be

hypersensitive.

This medicine may cause some common and serious side effects. Discuss the risks and

benefits of the Imatib tablets with the doctor before starting the treatment.

Common Side Effects
● Nausea

● Diarrhea

● Abdominal pain

● Joint pain

● Headache

● Weight gain

● Insomnia

● Vomiting

● Muscle pain

● Heartburn

● Indigestion

● Rash

● Bleeding

● Mouth ulcers

● Constipation

● Blurred vision

● Indigestion

● Dizziness

● Weight loss

● Change in taste

● Joint pain

Serious side effects

● Difficulty in breathing

● Irregular heartbeat

● Swelling around the eyes

● Pale skin

● Unusual bleeding

● Bloody stool

● Swelling of the hands and feet

● Bloating

● Presence of blood in cough

● Fatigue

Note – Immediately contact your doctor or medical practitioner if any side effects occur

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing

schedule.

Missed Dose
● It is advisable not to miss a dose. If you miss a scheduled dose of Imatib tablets, contact

your doctor immediately.

Overdose
● In case of an overdose of Imatib tablets, the doctor will provide emergency medical

treatment.

Usage
This medication is used in the treatment of chronic myeloid leukemia Acute lymphocytic

leukemia and gastrointestinal stromal tumor. Imatib tablets help to stop the growth of cancer

cells in the body. Take this medicine orally once a day with food. Do not take this medicine in

the wrong way as it may lead to some severe side effects. Avoid the consumption of alcohol. It

may increase the risk of dizziness. Keep yourself hydrated and maintain good nutrition while

having treatment with this medicine. Avoid eating grapefruit and drinking grapefruit juice.

Before starting treatment with Imatib medicine, please inform your doctor about your previous

medical history. If you experience any signs and symptoms while receiving this medication, do

not ignore those symptoms because it may lead to higher risk.

Contraception

○ Use suitable methods of contraception to prevent pregnancy while taking this

medicine.

● Children and adolescents

○ Imatib tablets are advisable for use in children and adolescents with CML.

Warnings For Female
● Pregnancy

○ Do not use Imatib medicine if you are planning to become pregnant. Avoid this

medication at the time of pregnancy.

● Breastfeeding

○ This medicine is not recommended for breastfeeding unless it is required. Please

consult with your doctor before starting treatment with this medication.

Precautions
● Close monitoring of thyroid hormones is required in patients suffering from

hypothyroidism.

● Imatib tablets may interact with other medications and cause some severe side effects.

● This medicine should be used with caution in patients who are suffering from heart

disease.

● In children, close monitoring of growth parameters is required during treatment with this

medicine.

● Inform your doctor if you experience any side effects like – nausea, abdominal pain,

difficulty in breathing, irregular heartbeat, and fatigue.

● This medicine may increase the risk of getting infections.

Cautions
● Do not drive or operate heavy machinery.

● Do not crush or break the tablet.

● Not safe for pregnant women.

● Do not breastfeed while receiving this medication.

Substitutes
● Imat

● Mitinib

● Imanib

● Levin

DESCRIPTION

  • Composition: Imatinib mesylate
  • Manufacturer: Cipla
  • Indication: Blood cancer
  • Packaging: Strip
  • Dosage Form: Tablet

PACKAGE

  • 100mg
  • 400mg
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