DASAKAST

DESCRIPTION

  • Composition : Dasakast
  • Manufacturer: Aprazer Healthcare
  • Indication: Blood Cancer
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

  • 50 mg

Brand name: Dasakast

Generic name: Dasatinib

Strength: 70 mg

Manufacturer: Aprazer

Dosage form: Tablet

Indication: Blood Cancer

Storage: Store at room temperature.

Overview
Dasakast is an anticancer formulation comprising Dasatinib. It belongs to the class of small molecule antineoplastic breakpoint cluster region-abelson (BCR-ABL) inhibitors. This medicine is used in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Dasakast is administered as an oral-use tablet with a glass of water. It should be taken in the same strength as prescribed by your medical practitioner. The medication should never be missed or overdosed unless recommended by your GP.

Pharmacodynamics
Dasatinib, at nanomolar concentrations, represses the latter kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Based on modeling studies, dasatinib is predicted to bind to varied conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines denoting variants of imatinib mesylate sensitive and resistant conditions. The compound hindered the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL.

Interactions
Dasakast (Dasatinib) tablets can interact with medicines, diseases, and alcohol. As per the severity of interactions, the following should be taken into consideration.

With Medicines

  • Cisapride
  • Diclofenac
  • BCG vaccine
  • Adalimumab
  • Alteplase
  • Dabigatran

With Diseases

  • Hepatic impairment
  • Heart and blood vessel disorder

With Alcohol

  • Alcohol can show significant interactions with the ingredients of Dasakast (Dasatinib) tablets. Please talk to your medical practitioner regarding the same prior to the therapy.

Contraindications

The following are some of the contraindications of Dasakast (Dasatinib) tablets:

  • Anemia, neutropenia, and thrombocytopenia
  • Anticoagulant therapy, bleeding, GI bleeding, and intracranial bleeding
  • Edema, pericardial effusion, and pleural effusion
  • Lactase deficiency
  • Tumor lysis syndrome
  • Pulmonary hypertension
  • Geriatric
  • Children, growth inhibition, infants, and neonates
  • Pregnancy
  • Breast-feeding

Alternate Brands

  • Dasacine
  • Sprycel

The following are some of the common adverse effects that are associated with the use of Dasakast tablets.

  • Joint pain
  • Bleeding gums
  • Constipation
  • Loss of appetite
  • Difficulty in breathing
  • Fatigue
  • Nausea
  • Infection
  • Low blood platelets
  • Muscle pain
  • Bone pain
  • Unusual tiredness
  • Chills
  • Skin rash
  • Weight loss
  • Tingling in the arms and feet
  • Vomiting
  • Anxiety
  • Diarrhea
  • Blurred vision
  • Swelling in your feet
  • Irregular heartbeat
  • Sore throat
  • Headache
  • Nasal congestion
  • Anemia
  • Unusual weakness
  • Difficulty with swallowing
  • Itching
  • Coughing up blood
  • Body pain
  • Dizziness
  • Weight gain

Take Dasakast (Dasatinib) tablets as per the prescription given by your general practitioner. Do not increase/decrease the dose strength.

Missed Dose
Do not skip the dose of Dasakast (Dasatinib) tablets. If you miss a dose, make sure to tell your healthcare provider about the same.

Overdose
Do not overdose on Dasakast (Dasatinib) tablets. If you experience the symptoms of overdose, make sure to tell your healthcare provider about the same.

Pregnancy
During pregnancy, Dasakast (Dasatinib) tablets should be administered only if the doctor prescribes them. Be sure to seek the advice of your health practitioner.

Breastfeeding
During breastfeeding, Dasakast (Dasatinib) tablets should be administered only if the doctor prescribes them. Be sure to seek the advice of your health practitioner.

Kidney
In kidney disease, Dasakast (Dasatinib) tablets should be given with caution.

Liver
In kidney disease, Dasakast (Dasatinib) tablets should be given with caution.

Alcohol
Alcohol and Dasakast (Dasatinib) tablets can interact with each other and cause severe reactions. Be sure to seek the advice of your health practitioner.

Driving
Do not drive after taking Dasakast (Dasatinib) tablets if you experience symptoms like dizziness and blurred vision.

DESCRIPTION

  • Composition : Dasakast
  • Manufacturer: Aprazer Healthcare
  • Indication: Blood Cancer
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

    • 50 mg
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