BEVACIZUMAB 100MG INJECTION (BEVATAS)

BEVACIZUMAB 100MG INJECTION (BEVATAS)

DESCRIPTION

PACKAGE

OVERVIEW & USAGE

Medicinal Details

Brand name:- Bevatas

Generic name:- Bevacizumab

Manufacturer:- Intas Pharmaceuticals Ltd

Strength:- 100mg and 400mg

Dosage:- Injection

Packaging:- Vial

Storage:- Store in a refrigerator

Overview

Bevatas is an effective formulation of Bevacizumab prescribed for the treatment of certain types of cancers (colorectal cancer, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer). Bevatas injection belongs to a group of biological response modifiers. This medicine is an anti-VEGF (Vascular endothelial growth factor) drug, which is used in the treatment of certain types of cancers. Bevatas injection has also been known as a promising and useful drug to treat patients suffering from severe and critical conditions of COVID-19.

Pharmacodynamics

Bevacizumab works by binding VEGF or circulating vascular endothelial-derived growth factor. It tends to block it from binding to its consequent receptors while effectively blunting downstream signaling. The effects of this compound have been demonstrated to re-establish normal vasculature at the tumor site leading to increased nutrient and oxygen supply. It also improves the delivery of chemotherapeutic agents to the target region. On the other hand, VEGF signaling is a vital component of certain processes such as:

  • angiogenesis
  • lymphangiogenesis
  • blood pressure regulation
  • wound healing
  • coagulation
  • renal filtration

Although blocking VEGF may lead to the inhibition of metastatic disease progression, it can also lead to unwanted effects because of the role of VEGF in several other physiologic processes.

Interactions

It is important to know the interactions of Bevatas (Bevacizumab) injection with other drugs and diseases, before starting treatment with this medication.

Medicine Interactions

  • Sunitinib
  • Topotecan
  • Pamidronate
  • Risedronate
  • Deferiprone
  • Palifermin

Disease Interactions

  • Gastrointestinal perforation
  • Bleeding
  • Hypertension
  • Proteinuria

Alcohol Interactions

  • Avoid consuming alcohol while receiving treatment with Bevatas (Bevacizumab) injection.

Contraindications

  • Bevatas (Bevacizumab) injection is not indicated for use in the following cases:-
  • Hypersensitivity
  • Allergy to Bevacizumab
  • Surgery

Side Effects

Side effects may occur during treatment with Bevatas (Bevacizumab) injection. Therefore, if side effects last longer than usual, contact your healthcare provider as soon as possible.

  • Chest pain
  • Sore throat
  • Fever
  • Dizziness
  • Loss of appetite
  • Body pain
  • Runny nose
  • Vomiting
  • Diarrhea
  • Seizures
  • Unusual bleeding
  • Nose bleeds
  • Dry skin
  • Swelling of the feet, fingers, lower legs.
  • Protein in urine
  • Taste change
  • Cough
  • Fatigue
  • Nasal congestion
  • Pale skin
  • Headache
  • Anxiety
  • Bleeding gums
  • Hypertension
  • Shortness of breath
  • Irregular heartbeat
  • Blood clots
  • High blood pressure
  • Decreased white blood cell count

Note:- It is advisable to contact a healthcare professional if side effects occur.

DOSAGE

Normal Dose

Bevatas (Bevacizumab) injection is administered by a qualified medical professional and the exact volume of dosage is decided by your healthcare provider according to your medical history and other health conditions.

Missed Dose

If you miss a scheduled dose of Bevatas (Bevacizumab) injection, contact your physician immediately to know the ways of coping with the skipped dose.

Overdose

In case of an overdose, the patient is advised to consult a health professional immediately if any unusual symptoms occur.

Warnings

Warnings For Females

  • Pregnancy

Bevatas (Bevacizumab) injection is not recommended for use in pregnant women. Contact your health professional to understand the risks and benefits.

  • Breastfeeding

Bevatas (Bevacizumab) injection may not be safe for use in women who are breastfeeding.

Precautions

  • Close monitoring of heart function is required during treatment with Bevatas (Bevacizumab) injection.
  • Use proper contraception during Bevatas (Bevacizumab) injection to avoid pregnancy.
  • Use of Bevatas (Bevacizumab) is not recommended in children under the age of 18.

Cautions

  • Do not self-administer Bevatas (Bevacizumab) injection.
  • Do not operate heavy machinery.
  • Do not freeze the Bevatas (Bevacizumab) injection.
  • Do not drive or initiate any task that requires concentration.
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