PONATINIB 45MG TABLET (ICLUSIG) UP TO 39% OFF

PONATINIB 45MG TABLET (ICLUSIG) UP TO 39% OFF

DESCRIPTION

  • Composition : Ponatinib
  • Manufacturer: ARIAD
  • Indication: Blood cancer
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

  • 15mg
  • 45mg

Brand name – Iclusig

Generic name – Ponatinib

Salt composition – Ponatinib

Manufacturer – ARIAD

Dosage form – Oral (tablet)

Packaging – Bottle

Indication – Blood cancer

Storage – Stored at room temperature.

Strength – 15 mg, 45 mg

Gender – Unisex

Prescription required – Yes

Description
Iclusig (Ponatinib 45mg) tablet is used in the treatment of adults with leukaemia (cancer of the white blood cells). It is used to treat the different stages of chronic myeloid leukemia (CML), namely chronic, accelerated, and blast phases. It is also used in the treatment of acute lymphoblastic leukemia (ALL) in certain patients who are ‘Philadelphia-chromosome positive’, which means those patients whose genes have rearranged themselves to form another special type of a chromosome called ‘Philadelphia-chromosome’. This chromosome leads to the development of Leukaemia.

Pharmacodynamics
Ponatinib is a multi-target kinase inhibitor. Its primary cellular target is the Bcr-Abl tyrosine kinase protein which is active and works to promote the progression of CML.

This protein arises from the fused Bcr and Abl gene which is commonly known as the Philadelphia chromosome. Ponatinib is especially useful in the treatment of resistant

CML because it works to inhibit the tyrosine kinase activity of Abl and T315I mutant kinases. The T315I mutation highly confers resistance in cells. It prevents other Bcr-Abl inhibitors from binding to the Abl kinase. Some other targets that ponatinib inhibits are members of the VEGFR, PDGFR, FGFR, EPH receptors, and SRC families of kinases, and KIT, RET, TIE2, and FLT3.

Contraindications
This medicine is not indicated to patients who have a known allergy to any of the ingredients of this medicine.

Side Effects Of Ponatinib 45mg Tablet

● Skin rash

● Chest pain

● Fever

● Nausea

● Joint or/and muscle pain

● Dry skin

● Constipation

● Weakness

● Drowsiness

● Cough

● Shortness of breath

● Fainting

● Chills

● Confusion

● Mood changes

● Blurred vision

● Unusual bleeding

● Back pain

● Yellowing skin

● Irregular heart rate

Dosage

Normal Dose
Take the dose exactly as your healthcare provider tells you. Do not increase or decrease the dose strength as per your own wish. Do not crush, chew, or break the tablet.

Missed Dose
When you miss a dose, make sure to tell your healthcare provider regarding the same to get proper guidance. Do not try to double the dose strength to catch up.

Overdose
Seek emergency medical support.

Usage Of Medicine
Iclusig (Ponatinib) tablet is used in the treatment of:

● chronic myeloid leukemia, and

● acute lymphoblastic leukemia.

Warning And Precautions

● Take the dose exactly as your healthcare provider tells you. Do not increase or decrease the dose strength as per your wish. Do not crush, chew, or break the tablet.

● Do tell your healthcare provider beforehand about your medical condition and medical history, along with the list of medicines you already take.

● In patients with kidney disease, administer this medicine with utmost caution.

● In patients with liver disease, administer this medicine with utmost caution.

● During pregnancy/breastfeeding, take it only if your healthcare provider prescribes it. Make sure to talk about the potential risks and benefits.

DESCRIPTION

  • Composition : Ponatinib
  • Manufacturer: ARIAD
  • Indication: Blood cancer
  • Packaging: Bottle
  • Dosage Form: Tablet

PACKAGE

  • 15mg
  • 45mg
Top
    wpChatIcon