Overview and Usage

Brand name- Erlonat

Generics- Erlotinib Hydrochloride

Manufacturer- NATCO Pharma

Dosage form- Tablet

Route of Administration- oral

Strength- 100, 150mg

Composition- Erlotinib Hydrochloride

Packaging- bottle

Indication- non-small cell lung cancer (NSCLC) and pancreatic cancer.

Storage- Store at room temperature (10-30°C)

Class of drug- Kinase inhibitor

Mechanism Of Action

Erlonat 100 mg belongs to a class of medications called kinase inhibitors. It works by blocking the action of abnormal protein that signals cancer cells to multiply. This in turn helps to slow or inhibit the spread of cancer cells

Side Effects-

Rashes in the majority of patients.

Diarrhea, Loss of appetite, Fatigue, Partial Hair Loss.

Rarely, ingrown hairs, like eyelashes


It is the study of drug effects and what the medicine does to the body

It inhibits the intracellular phosphorylation of tyrosine kinase associated with epidermal growth factor (EGFR). The specificity of inhibition concerning other tyrosine kinase receptors has not been fully characterized. EGFR is also expressed on the cell surface of normal cells and cancer cells


Study of what the body does to the medicine. Erlonat is around 60% absorbed after administration into the body and its bioavailability is increased by food to almost 100%. Its half-life is 36 hours and it is cleared majorly by the CYP3A4 enzyme present in the body.

Minimum effect concentration (MEC)

A minimum concentration of medicine in the blood is required to produce the therapeutic effects. Its predefined therapeutic MEC is (0.8μg/ml)

Minimum toxic concentration (MTC)

Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC is 1.25μg/ml

Bioavailability Rate

After oral administration, the medicine archived approximately 60% bioavailability, with administration with food enhancing bioavailability to upwards of 100%

Shelf Life  

Shelf life is the period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at the time of manufacture.

Its shelf life is 2years


  • Tarceva
  • Carac

Alternate Brands

  • Erlocip by Cipla Ltd.
  • Erlotib 150mg Tablet by Intas.
  • Zyceva 150mg Tablet by Zydus.
  • Erleva 100 mg/150 mg by Glenmark.
  • Erlotirel 100 mg/150 mg by Reliance Life Sciences.


Consult your doctor before taking this medicine, if you:

Are allergic to personal 100 mg, or any of the ingredients of this medicine or have severe liver disease or severe kidney disease

If one uses contact lenses and/or has a history of eye problems such as severe dry eyes
Side effects

Common Side Effects

  • Abdominal pain
  • Bone pain
  • Breathlessness
  • Constipation
  • Cough
  • Diarrhea
  • Fatigue
  • Fever
  • Infection
  • Muscle pain
  • Nausea
  • Rash
  • Stomatitis (Inflammation of the mouth)
  • Vomiting
  • Weight loss

Serious Side Effects

Fatigue, loss of appetite, partial hair loss, diarrhea, mouth sores, vomiting, rashes, weight loss, dry skin, eye irritation, weight decrease, infection, edema, pyrexia, constipation, bone pain, dyspnea, stomatitis, and myalgia.


Missed Dose

If the patient misses a dose of erlonat 100 mg, skip it and continue with the normal schedule. No need to double the dose


Get the emergency medical treatment and contact your physician


Which disease area
non-small cell lung cancer (NSCLC) and pancreatic cancer


General Warning And Precautions

Erlonat 100 mg causes skin rash, dryness, or other irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Stop using skin products that cause dryness or irritation, such as acne medications, harsh soaps or skin cleansers, or skin products that have alcohol.


It is usually taken on an empty stomach once a day, at least 1 hour before or 2 hours after eating a meal or snack. Take erlonat at around the same time every day.